well, sort of. I updated some wordpress setups from 2.0.7 to 2.1. In many cases the update worked like a charm. In some cases I had problems with the new Wysiwyg editor. Update: this is solved now.
I even uninstalled the software (not the database) and made a new install from scratch. The problem does still exists in one blog, all others are running fine. This seems to be quite esoteric because both times, the same software ist used. On one server it throws errors, on another everything works fine. The error is thrown while using the insert link tool, the box can’t be closed:
Error: this.frame.tinyMCEPopup.restoreSelection is not a function
Source File: http://www.example.com/wp-includes/js/tinymce/tiny_mce_gzip.php?ver=20061113&theme=advanced&language=&plugins=inlinepopups%2Cautosave%2Cspellchecker%2Cpaste%2Cwordpressâ?©=&index=0
Line: 1082
I’m using firefox 2 but this can’t be the problem because one blog setup works, the other blog does not. This, for example is the same browser on winxp using the other blog which just looks great and works as intended: 
So if it’s not the browser, why do some people say, this is browser releated? I don’t know, maybe they can answer it themselves: Sajonara: geht nicht. / Sajonara: geht doch. And indeed, Sajonara analyzes a firefox security setting as the problem for the german version of Firefox. ??!! I must admit that he must be kidding because, I’m using the english Firefox version and get both: a working and a non working WP 2.1 version. This solution by Alexander Trust might fix the problem (for him) but this ain’t the true source of the problem. And it is very interesting for me, that I only have the first checkbox only in the advanced javascript settings enabled and not all and the editor is working properly as well.
Update: After some more searching, I found a post by Stephan Janosch who pushed me finally into the right direction: As often when it’s esoteric with webapps, it’s a simple cache related issue. Nothing more and nothing less.